Toll receptor is one type of Pattern Recognition Receptors meant for the recognition of pathogen associated molecular patterns (PAMPS) involve in innate and adaptive immune response. Their modulation results in the malfunctioning of the immune system. As a result, toll receptor may mediate number of organ disorders. The disorders can be treated by the modulation of the pathway via toll like receptors. Toll like receptor specifically acts by the MYD88 dependent pathway and MYD88 independent pathway. Disorders evidenced to be mediated by the toll like receptors involve skin disorders, neurological, cardiac, respiratory, metabolic etc. The present article sites the role of these clever proteins (toll receptors) in the pathophysiology of various associated diseases.
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